The effect of characteristics of proteins fed during gestation and lactation on development of metabolic syndrome in dams and male offspring of Wistar rats
نویسندگان
چکیده
OBJECTIVE The objective of the study is to examine the role of characteristics of proteins in maternal and weaning diets on risk of metabolic syndrome in male offspring. METHODS Pregnant Wistar rats were allocated to two groups (n = 12) and were fed the AIN-93G diets based on either intact protein-based diet (IPD) or mixed amino acid-based diet (AAD) from day 3 of gestation throughout gestation and lactation. Male offspring were weaned to either an IPD or AAD diet for 18 weeks. RESULTS In dams, AAD group had lower body weight in post-partum period and higher pulse rate compared with IPD group. In pups born to AAD dams, birth weight and body weight were significantly lower, and systolic blood pressure and fasting blood glucose were significantly higher compared with those born to IPD dams. Fat/weight ratio, insulin and homeostasis model assessment of insulin resistance were not influenced by either maternal or weaning diet. CONCLUSIONS These results indicate that the physico-chemical structure of proteins fed to dams is important in altering risk factors of metabolic syndrome in the offspring, while weaning diets do not seem to play a role. IPD had more favourable effect than AAD. These results may also indicate that dietary recommendations during development must be updated based on physiological properties of dietary proteins that are beyond their nutritional role.
منابع مشابه
Soya protein- and casein-based nutritionally complete diets fed during gestation and lactation differ in effects on characteristics of the metabolic syndrome in male offspring of Wistar rats.
The AIN-93G diets based on soya protein or casein were fed to pregnant Wistar rats from day 3 of gestation and compared for their effects on characteristics of the metabolic syndrome in male offspring. Pregnant rats were randomised to either a casein (C) or soya protein (S) diet (n 12) during gestation only (Expt 1) or during gestation and lactation (Expt 2). Male offspring were weaned to eithe...
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We hypothesized that protein source in the nutritionally adequate AIN-93G diets fed during gestation, lactation, and weaning influences food intake (FI) regulation in male offspring of Wistar rats. Pregnant rats were fed the recommended casein-based (C) or soy protein-based (S) diet during gestation (experiment 1) or during gestation and lactation (experiment 2). Pups (n = 12 per group) weaned ...
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عنوان ژورنال:
دوره 3 شماره
صفحات -
تاریخ انتشار 2017